Reticulocyte maturation in vitro and in vivo.

S 969 Marchiafava disease, i.e. PNH. When this is disregarded. the disease may remain unrecognized for a long time, until the typical syndrome of paroxysmal nocturnal hemoglobinuria becomes apparent. In some cases the disorder begins with thrombocytopenic purpura (TP), s hile the typical PIH appears several years (in one female patient 12 yr) after the removal ofthe spleen for TP. In other cases. transforniation of the hypoplastic bone marros in a partiallv hyperplastic one with predominance of cry throid cells, imitating erythromyclosis developed spontaneously . Because of the permanent character of the intravascular hernolysis, we suggest that the title PIH (permanent intravascular hemol sis) is more correct than that of PNH which onI reflects a moment of the clinical moving picture. The development of symptoms of PIH on the background of a hypoplastic bone marros is considered as the second phase of the Strubing-Marchiafasa disease. The myeloid metaplasia of the spleen is considered as the third phase. (i-I.